| 9/4/2010 | Susquehanna 6 @ Moravian Greyhounds 12 | † |
| 9/11/2010 | Juniata Eagles 3 @ Susquehanna 45 | † |
| 9/18/2010 | Muhlenberg Mules 21 @ Susquehanna 14 | † |
| 9/25/2010 | Susquehanna 7 @ Ursinus Bears 24 | † |
| 10/2/2010 | Franklin & Marshall Diplomats 41 @ Susquehanna 20 | † |
| 10/9/2010 | Susquehanna 0 @ McDaniel Green Terror 35 | † |
| 10/16/2010 | Dickinson Red Devils 28 @ Susquehanna 24 | † |
| 10/23/2010 | Johns Hopkins Blue Jays 49 @ Susquehanna 24 | † |
| 10/30/2010 | Susquehanna 50 @ Gettysburg Bullets 61 | † |
| 11/6/2010 | Susquehanna 14 @ Worcester Polytechnic Engineers 7 |