| 9/4/2010 | Worcester Polytechnic Engineers 3 @ Salve Regina 6 | |
| 9/11/2010 | Salve Regina 19 @ Hartwick Hawks 20 | |
| 9/18/2010 | Salve Regina 3 @ Framingham State Rams 14 | † |
| 9/25/2010 | Endicott Power Gulls 29 @ Salve Regina 28 | † |
| 10/2/2010 | Salve Regina 5 @ Western New England Golden Bears 10 | † |
| 10/9/2010 | Salve Regina 28 @ UMass Dartmouth Corsairs 6 | † |
| 10/16/2010 | Curry Colonels 7 @ Salve Regina 31 | † |
| 10/23/2010 | Salve Regina 13 @ MIT Engineers 7 | † |
| 10/30/2010 | Plymouth State Panthers 14 @ Salve Regina 30 | † |
| 11/6/2010 | Nichols Bison 0 @ Salve Regina 6 | † |