| 9/11/2010 | Union NY 20 @ Ithaca Bombers 28 | |
| 9/25/2010 | Rochester Yellow Jackets 14 @ Union NY 16 | † |
| 10/2/2010 | Union NY 25 @ Worcester Polytechnic Engineers 17 | † |
| 10/9/2010 | Union NY 35 @ Hobart Statesmen 41 2OT | † |
| 10/16/2010 | St Lawrence Saints 23 @ Union NY 14 | † |
| 10/23/2010 | Salisbury Seagulls 52 @ Union NY 21 | |
| 10/30/2010 | Union NY 7 @ Rensselaer Engineers 21 | † |
| 11/6/2010 | Merchant Marine Mariners 28 @ Union NY 21 | † |
| 11/13/2010 | Union NY 15 @ Springfield Pride 26 |