| 9/4/2010 | Ursinus 21 @ Albright Lions 13 | |
| 9/11/2010 | Ursinus 10 @ Franklin & Marshall Diplomats 7 | † |
| 9/18/2010 | Juniata Eagles 0 @ Ursinus 41 | † |
| 9/25/2010 | Susquehanna Crusaders 7 @ Ursinus 24 | † |
| 10/2/2010 | Ursinus 49 @ Gettysburg Bullets 39 | † |
| 10/16/2010 | Johns Hopkins Blue Jays 17 @ Ursinus 26 | † |
| 10/23/2010 | McDaniel Green Terror 18 @ Ursinus 43 | † |
| 10/30/2010 | Ursinus 17 @ Moravian Greyhounds 24 | † |
| 11/6/2010 | Ursinus 20 @ Muhlenberg Mules 27 | † |
| 11/13/2010 | Dickinson Red Devils 21 @ Ursinus 41 | † |