| 9/4/2010 | Delaware Valley Aggies 27 @ Muhlenberg 7 | |
| 9/18/2010 | Muhlenberg 21 @ Susquehanna Crusaders 14 | † |
| 9/25/2010 | Gettysburg Bullets 27 @ Muhlenberg 33 1OT | † |
| 10/2/2010 | Muhlenberg 30 @ Johns Hopkins Blue Jays 27 | † |
| 10/9/2010 | Juniata Eagles 3 @ Muhlenberg 38 | † |
| 10/16/2010 | Muhlenberg 29 @ McDaniel Green Terror 0 | † |
| 10/23/2010 | Franklin & Marshall Diplomats 17 @ Muhlenberg 7 | † |
| 10/30/2010 | Muhlenberg 26 @ Dickinson Red Devils 13 | † |
| 11/6/2010 | Ursinus Bears 20 @ Muhlenberg 27 | † |
| 11/13/2010 | Muhlenberg 13 @ Moravian Greyhounds 14 | † |
| 11/20/2010 | Muhlenberg 14 @ Wesley Wolverines 53 (D3 Playoffs Round 1) |