| 9/4/2010 | East Texas Baptist Tigers 33 @ Wisconsin-La Crosse 20 | |
| 9/11/2010 | Mary Hardin-Baylor Crusaders 24 @ Wisconsin-La Crosse 19 | |
| 9/25/2010 | Wisconsin-La Crosse 24 @ Missouri S&T Miners 31 | |
| 10/2/2010 | Wisconsin-La Crosse 17 @ Wisconsin-Oshkosh Titans 28 | † |
| 10/9/2010 | Wisconsin-River Falls Falcons 20 @ Wisconsin-La Crosse 37 | † |
| 10/16/2010 | Wisconsin-Platteville Pioneers 21 @ Wisconsin-La Crosse 6 | † |
| 10/23/2010 | Wisconsin-La Crosse 17 @ Wisconsin-Stevens Point Pointers 31 | † |
| 10/30/2010 | Wisconsin-La Crosse 29 @ Wisconsin-Stout Blue Devils 28 | † |
| 11/6/2010 | Wisconsin-Eau Claire Blugolds 14 @ Wisconsin-La Crosse 49 | † |
| 11/13/2010 | Wisconsin-La Crosse 0 @ Wisconsin-Whitewater Warhawks 24 | † |