| 9/4/2010 | St Augustine's Falcons 20 @ Catawba 17 | |
| 9/11/2010 | Catawba 59 @ Livingstone Blue Bears 8 | |
| 9/18/2010 | Shaw Bears 21 @ Catawba 32 | |
| 10/2/2010 | Catawba 35 @ Wingate Bulldogs 28 | † |
| 10/9/2010 | Brevard Tornados 21 @ Catawba 31 | † |
| 10/16/2010 | Carson-Newman Eagles 42 @ Catawba 16 | † |
| 10/23/2010 | Catawba 28 @ Newberry Wolves 25 | † |
| 10/30/2010 | Catawba 38 @ Mars Hill Lions 28 | † |
| 11/6/2010 | Tusculum Pioneers 54 @ Catawba 44 | † |
| 11/13/2010 | Catawba 17 @ Lenoir-Rhyne Bears 31 | † |