| 8/28/2010 | Washburn Ichabods 34 @ Colorado Mines 29 | |
| 9/4/2010 | Colorado Mines 52 @ South Dakota Tech Jackrabbits 24 | |
| 9/18/2010 | Colorado Mines 49 @ New Mexico Highlands Cowboys 21 | † |
| 9/25/2010 | Western New Mexico Mustangs 0 @ Colorado Mines 43 | † |
| 10/2/2010 | Colorado Mines 38 @ Fort Lewis Skyhawks 28 | † |
| 10/9/2010 | Colorado State -Pueblo ThunderWolves 16 @ Colorado Mines 19 | † |
| 10/16/2010 | Mesa State Mavericks 10 @ Colorado Mines 46 | † |
| 10/23/2010 | Colorado Mines 39 @ Western State Mountaineers 13 | † |
| 10/30/2010 | Adams State Grizzlies 17 @ Colorado Mines 24 | † |
| 11/6/2010 | Colorado Mines 31 @ Chadron State Eagles 38 | † |
| 11/13/2010 | Nebraska-Kearney Lopers 53 @ Colorado Mines 55 3OT | † |
| 11/20/2010 | Colorado Mines 13 @ Grand Valley State Lakers 35 |