| 9/2/2010 | Midwestern State Mustangs 52 @ New Mexico Highlands 6 | |
| 9/11/2010 | New Mexico Highlands 6 @ Panhandle State Aggies 14 | |
| 9/18/2010 | Colorado Mines Orediggers 49 @ New Mexico Highlands 21 | † |
| 9/25/2010 | New Mexico Highlands 6 @ Mesa State Mavericks 40 | † |
| 10/2/2010 | Western State Mountaineers 31 @ New Mexico Highlands 32 | † |
| 10/9/2010 | New Mexico Highlands 0 @ Adams State Grizzlies 55 | † |
| 10/16/2010 | Chadron State Eagles 41 @ New Mexico Highlands 19 | † |
| 10/23/2010 | New Mexico Highlands 13 @ Nebraska-Kearney Lopers 38 | † |
| 10/30/2010 | New Mexico Highlands 0 @ Colorado State -Pueblo ThunderWolves 66 | † |
| 11/6/2010 | Western New Mexico Mustangs 38 @ New Mexico Highlands 13 | † |
| 11/13/2010 | New Mexico Highlands 13 @ Fort Lewis Skyhawks 36 | † |