| 8/28/2010 | South Dakota Tech 13 @ Montana Tech Orediggers 6 | |
| 9/4/2010 | Colorado Mines Orediggers 52 @ South Dakota Tech 24 | |
| 9/18/2010 | South Dakota Tech 24 @ Valley City State Vikings 21 | † |
| 9/25/2010 | South Dakota Tech 41 @ Dakota State Trojans 14 | † |
| 10/2/2010 | Mayville State Comets 10 @ South Dakota Tech 58 | † |
| 10/9/2010 | Jamestown Jimmies 7 @ South Dakota Tech 31 | † |
| 10/16/2010 | South Dakota Tech 10 @ Minot State Beavers 6 | † |
| 10/23/2010 | Dickinson State Blue Hawks 24 @ South Dakota Tech 14 | † |
| 10/30/2010 | Black Hills State Yellow Jackets 13 @ South Dakota Tech 20 | † |