| 8/28/2010 | Mary Marauders 3 @ Chadron State 35 | |
| 9/4/2010 | Chadron State 3 @ Pittsburg State Gorillas 14 | |
| 9/18/2010 | Western State Mountaineers 7 @ Chadron State 40 | † |
| 9/25/2010 | Chadron State 21 @ Adams State Grizzlies 10 | † |
| 10/2/2010 | Chadron State 30 @ Colorado State -Pueblo ThunderWolves 33 | † |
| 10/9/2010 | Nebraska-Kearney Lopers 35 @ Chadron State 21 | † |
| 10/16/2010 | Chadron State 41 @ New Mexico Highlands Cowboys 19 | † |
| 10/23/2010 | Western New Mexico Mustangs 7 @ Chadron State 31 | † |
| 10/30/2010 | Chadron State 38 @ Fort Lewis Skyhawks 7 | † |
| 11/6/2010 | Colorado Mines Orediggers 31 @ Chadron State 38 | † |
| 11/13/2010 | Chadron State 31 @ Mesa State Mavericks 21 | † |