| 9/2/2010 | Mesa State 3 @ Missouri Western Griffons 36 | |
| 9/18/2010 | Mesa State 9 @ Nebraska-Kearney Lopers 31 | † |
| 9/25/2010 | New Mexico Highlands Cowboys 6 @ Mesa State 40 | † |
| 10/2/2010 | Mesa State 10 @ Western New Mexico Mustangs 20 | † |
| 10/9/2010 | Fort Lewis Skyhawks 14 @ Mesa State 31 | † |
| 10/16/2010 | Mesa State 10 @ Colorado Mines Orediggers 46 | † |
| 10/23/2010 | Colorado State -Pueblo ThunderWolves 26 @ Mesa State 14 | † |
| 10/30/2010 | Western State Mountaineers 28 @ Mesa State 33 | † |
| 11/6/2010 | Mesa State 34 @ Adams State Grizzlies 41 | † |
| 11/13/2010 | Chadron State Eagles 31 @ Mesa State 21 | † |