| 9/2/2010 | Merrimack 26 @ Slippery Rock Rockets 45 | |
| 9/18/2010 | Merrimack 29 @ Bryant Bulldogs 46 | |
| 9/24/2010 | Merrimack 42 @ Stonehill Skyhawks 39 | † |
| 10/2/2010 | Saint Anselm Hawks 14 @ Merrimack 52 | † |
| 10/8/2010 | Merrimack 28 @ Bentley Falcons 31 | † |
| 10/16/2010 | Assumption Greyhounds 23 @ Merrimack 49 | † |
| 10/23/2010 | Merrimack 25 @ New Haven Chargers 27 | † |
| 10/30/2010 | American Int'l Yellow Jackets 59 @ Merrimack 19 | † |
| 11/6/2010 | Southern Connecticut Owls 49 @ Merrimack 32 | † |
| 11/13/2010 | Merrimack 46 @ Pace Setters 14 | † |