| 9/2/2010 | Northern Michigan 6 @ Minnesota State-Mankato Mavericks 7 | |
| 9/11/2010 | Findlay Oilers 10 @ Northern Michigan 49 | † |
| 9/18/2010 | Northern Michigan 31 @ Northwood Timberwolves 17 | † |
| 9/25/2010 | Ashland Eagles 19 @ Northern Michigan 23 | † |
| 10/2/2010 | Northern Michigan 18 @ Wayne State MI Warriors 26 | † |
| 10/9/2010 | Northern Michigan 7 @ Grand Valley State Lakers 28 | † |
| 10/16/2010 | Ferris State Bulldogs 20 @ Northern Michigan 22 | † |
| 10/23/2010 | Indianapolis Greyhounds 6 @ Northern Michigan 5 | † |
| 10/30/2010 | Northern Michigan 43 @ Tiffin Dragons 14 | † |
| 11/6/2010 | Saginaw Valley State Cardinals 24 @ Northern Michigan 17 | † |
| 11/13/2010 | Northern Michigan 0 @ Michigan Tech Huskies 12 | † |