| 9/4/2010 | Fayetteville State 0 @ UNC Pembroke Braves 39 | |
| 9/11/2010 | Bowie State Bulldogs 7 @ Fayetteville State 27 | † |
| 9/18/2010 | Elizabeth City State Vikings 38 vs Fayetteville State 26 (Rocky Mount NC) | † |
| 9/25/2010 | Winston-Salem State Rams 31 @ Fayetteville State 14 | † |
| 10/2/2010 | Fayetteville State 36 @ St Augustine's Falcons 42 | † |
| 10/9/2010 | Fayetteville State 21 @ Virginia State Trojans 14 | † |
| 10/16/2010 | Fayetteville State 27 @ Shaw Bears 34 | † |
| 10/23/2010 | Livingstone Blue Bears 6 @ Fayetteville State 59 | † |
| 10/30/2010 | Johnson C Smith Golden Bulls 6 @ Fayetteville State 64 | † |
| 11/6/2010 | Virginia Union Panthers 28 @ Fayetteville State 44 | † |