| 9/11/2010 | Georgetown Hoyas 28 @ Lafayette 24 | † |
| 9/18/2010 | Lafayette 14 @ Pennsylvania Quakers 19 | |
| 9/25/2010 | Lafayette 33 @ Princeton Tigers 36 1OT | |
| 10/2/2010 | Harvard Crimson 35 @ Lafayette 10 | |
| 10/9/2010 | Lafayette 28 @ Columbia Lions 42 | |
| 10/16/2010 | Stony Brook Seawolves 21 @ Lafayette 28 | |
| 10/23/2010 | Lafayette 10 @ Fordham Rams 14 | † |
| 10/30/2010 | Lafayette 33 @ Bucknell Bison 22 | † |
| 11/6/2010 | Lafayette 14 @ Colgate Red Raiders 24 | † |
| 11/13/2010 | Holy Cross Crusaders 37 @ Lafayette 27 | † |
| 11/20/2010 | Lehigh Mountain Hawks 20 @ Lafayette 13 | † |