| 9/4/2010 | C W Post Pioneers 20 @ American Int'l 11 | |
| 9/11/2010 | American Int'l 14 @ Stony Brook Seawolves 31 | |
| 9/18/2010 | Stonehill Skyhawks 12 @ American Int'l 14 | † |
| 9/23/2010 | American Int'l 7 @ Southern Connecticut Owls 28 | † |
| 10/2/2010 | Bentley Falcons 14 @ American Int'l 17 | † |
| 10/9/2010 | American Int'l 27 @ Saint Anselm Hawks 7 | † |
| 10/16/2010 | New Haven Chargers 13 @ American Int'l 0 | † |
| 10/30/2010 | American Int'l 59 @ Merrimack Warriors 19 | † |
| 11/6/2010 | Pace Setters 31 @ American Int'l 69 | † |
| 11/13/2010 | American Int'l 35 @ Assumption Greyhounds 10 | † |