| 9/4/2010 | Fort Lewis Skyhawks 10 @ Montana State 59 | |
| 9/11/2010 | Montana State 22 @ Washington State Cougars 23 | |
| 9/18/2010 | Drake Bulldogs 21 @ Montana State 48 | |
| 9/25/2010 | Eastern Washington Eagles 7 @ Montana State 30 | † |
| 10/2/2010 | Montana State 64 @ Sacramento State Hornets 61 1OT | † |
| 10/9/2010 | Portland State Vikings 31 @ Montana State 44 | † |
| 10/16/2010 | Montana State 7 @ Northern Arizona Lumberjacks 34 | † |
| 10/23/2010 | Northern Colorado Bears 35 @ Montana State 37 | † |
| 10/30/2010 | Montana State 23 @ Idaho State Bengals 20 1OT | † |
| 11/6/2010 | Weber State Wildcats 10 @ Montana State 24 | † |
| 11/20/2010 | Montana State 21 @ Montana Grizzlies 16 | † |
| 12/4/2010 | North Dakota State Bison 42 @ Montana State 17 |