| 9/4/2010 | Bucknell Bison 13 @ Duquesne 17 | |
| 9/11/2010 | Dayton Flyers 31 @ Duquesne 35 | |
| 9/18/2010 | Duquesne 6 @ Delaware Blue Hens 30 | |
| 9/25/2010 | Albany NY Great Danes 17 @ Duquesne 28 | † |
| 10/2/2010 | Monmouth NJ Hawks 44 @ Duquesne 17 | † |
| 10/9/2010 | Duquesne 29 @ Central Conn Blue Devils 31 | † |
| 10/16/2010 | Sacred Heart Pioneers 17 @ Duquesne 37 | † |
| 10/23/2010 | Duquesne 21 @ Wagner Seahawks 20 | † |
| 10/30/2010 | Duquesne 11 @ Robert Morris Colonials 34 | † |
| 11/13/2010 | St Francis PA Fighting Saints 17 @ Duquesne 41 | † |
| 11/20/2010 | Duquesne 37 @ Bryant Bulldogs 29 | † |