| 9/4/2010 | Lehigh 28 @ Drake Bulldogs 14 | |
| 9/11/2010 | Villanova Wildcats 35 @ Lehigh 0 | |
| 9/18/2010 | Princeton Tigers 22 @ Lehigh 35 | |
| 9/25/2010 | Lehigh 10 @ New Hampshire Wildcats 31 | |
| 10/9/2010 | Fordham Rams 17 @ Lehigh 21 | † |
| 10/16/2010 | Lehigh 21 @ Harvard Crimson 19 | |
| 10/23/2010 | Bucknell Bison 10 @ Lehigh 32 | † |
| 10/30/2010 | Colgate Red Raiders 14 @ Lehigh 44 | † |
| 11/6/2010 | Lehigh 34 @ Holy Cross Crusaders 17 | † |
| 11/13/2010 | Lehigh 24 @ Georgetown Hoyas 7 | † |
| 11/20/2010 | Lehigh 20 @ Lafayette Leopards 13 | † |
| 11/27/2010 | Lehigh 14 @ Northern Iowa Panthers 7 (FBS Playoffs) | |
| 12/4/2010 | Lehigh 20 @ Delaware Blue Hens 42 |