| 9/4/2010 | San Jose State 3 @ Alabama Crimson Tide 48 | |
| 9/11/2010 | San Jose State 14 @ Wisconsin Badgers 27 | |
| 9/18/2010 | Southern Utah Thunderbirds 11 @ San Jose State 16 | |
| 9/25/2010 | San Jose State 3 @ Utah Utes 56 | |
| 10/2/2010 | UC Davis Aggies 14 @ San Jose State 13 | |
| 10/9/2010 | San Jose State 13 @ Nevada Wolf Pack 35 | † |
| 10/16/2010 | Boise State Broncos 48 @ San Jose State 0 | † |
| 10/23/2010 | Fresno State Bulldogs 33 @ San Jose State 18 | † |
| 10/30/2010 | San Jose State 27 @ New Mexico State Aggies 29 | † |
| 11/13/2010 | Utah State Aggies 38 @ San Jose State 34 | † |
| 11/20/2010 | San Jose State 7 @ Hawaii Warriors 41 | † |
| 11/27/2010 | Louisiana Tech Bulldogs 45 @ San Jose State 38 | † |
| 12/4/2010 | San Jose State 23 @ Idaho Vandals 26 1OT | † |