| 9/3/2005 | Northern Illinois | 17 | @ | #20 Michigan | 33 | ||||
| 9/10/2005 | Northern Illinois | 37 | @ | Northwestern | 38 | ||||
| 9/17/2005 | Tennessee Tech | 3 | @ | Northern Illinois | 42 | ||||
| 9/24/2005 | Northern Illinois | 42 | @ | Akron | 48 | OT | MAC | ||
| 10/5/2005 | Miami-Ohio | 27 | @ | Northern Illinois | 38 | MAC | |||
| 10/15/2005 | Eastern Michigan | 8 | @ | Northern Illinois | 24 | MAC | |||
| 10/22/2005 | Northern Illinois | 34 | @ | Kent St | 3 | MAC | |||
| 10/29/2005 | Ball State | 31 | @ | Northern Illinois | 17 | MAC | |||
| 11/5/2005 | Northern Illinois | 31 | @ | Central Michigan | 28 | MAC | |||
| 11/16/2005 | Northern Illinois | 35 | @ | Toledo | 17 | MAC | |||
| 11/23/2005 | Western Michigan | 7 | @ | Northern Illinois | 42 | MAC | |||
| 12/1/2005 | Akron | 31 | vs | Northern Illinois | 30 | MAC | MAC CG |