| 9/5/2005 | NC A&T | 22 | vs | North Carolina Central | 23 | Raleigh NC | |||
| 9/10/2005 | Norfolk St | 14 | @ | NC A&T | 16 | MEAC | |||
| 9/15/2005 | Hampton | 23 | @ | NC A&T | 14 | MEAC | |||
| 9/24/2005 | NC A&T | 9 | @ | Elon | 12 | ||||
| 10/1/2005 | NC A&T | 16 | vs | Tennessee St | 3 | Indianapolis IN | |||
| 10/8/2005 | NC A&T | 40 | vs | Morgan St | 33 | 2 OT | MEAC | Landover MD | |
| 10/15/2005 | Delaware St | 23 | @ | NC A&T | 13 | MEAC | |||
| 10/22/2005 | NC A&T | 0 | @ | Howard | 16 | MEAC | |||
| 10/29/2005 | Bethune-Cookman | 54 | @ | NC A&T | 17 | MEAC | |||
| 11/5/2005 | NC A&T | 14 | @ | Florida A&M | 24 | MEAC | |||
| 11/19/2005 | S Carolina St | 43 | vs | NC A&T | 27 | MEAC | Charlotte NC |