| 9/3/2005 | Jackson St | 7 | vs | Hampton | 20 | Detroit MI | |||
| 9/10/2005 | Jackson St | 14 | vs | Tennessee St | 20 | OT | Memphis TN | ||
| 9/17/2005 | Texas Southern | 21 | @ | Jackson St | 24 | SWAC | |||
| 9/24/2005 | Jackson St | 33 | @ | MS Valley St | 14 | SWAC | |||
| 10/8/2005 | Alabama St | 44 | @ | Jackson St | 23 | SWAC | |||
| 10/15/2005 | Jackson St | 14 | @ | Southern Univ | 20 | SWAC | |||
| 10/22/2005 | Grambling | 52 | @ | Jackson St | 21 | SWAC | |||
| 10/29/2005 | Ark Pine Bluff | 64 | @ | Jackson St | 36 | SWAC | |||
| 11/5/2005 | Jackson St | 6 | @ | Alabama A&M | 52 | SWAC | |||
| 11/12/2005 | Jackson St | 9 | @ | Prairie View | 27 | SWAC | |||
| 11/19/2005 | Alcorn St | 31 | @ | Jackson St | 14 | SWAC |