| 9/3/2005 | Missouri State | 17 | @ | Arkansas | 49 | ||||
| 9/10/2005 | Quincy | 14 | @ | Missouri State | 51 | ||||
| 9/17/2005 | SE Missouri St | 21 | @ | Missouri State | 45 | ||||
| 10/1/2005 | Missouri State | 23 | @ | Southern Illinois | 30 | OT | GW | ||
| 10/8/2005 | Northern Iowa | 21 | @ | Missouri State | 24 | GW | |||
| 10/15/2005 | Missouri State | 28 | @ | Western Kentucky | 37 | GW | |||
| 10/22/2005 | Missouri State | 7 | @ | Youngstown St | 31 | GW | |||
| 10/29/2005 | Indiana St | 27 | @ | Missouri State | 31 | GW | |||
| 11/5/2005 | Illinois St | 48 | @ | Missouri State | 23 | GW | |||
| 11/12/2005 | Missouri State | 24 | @ | Western Illinois | 34 | GW |