| 9/10/2005 | Alabama A&M | 0 | @ | Grambling | 44 | SWAC | |||
| 9/17/2005 | Grambling | 14 | @ | Washington St | 48 | Seattle WA | |||
| 10/1/2005 | Grambling | 50 | vs | Prairie View | 7 | SWAC | Dallas TX | ||
| 10/8/2005 | MS Valley St | 22 | @ | Grambling | 37 | SWAC | |||
| 10/15/2005 | Grambling | 26 | @ | Ark Pine Bluff | 23 | SWAC | |||
| 10/22/2005 | Grambling | 52 | @ | Jackson St | 21 | SWAC | |||
| 10/29/2005 | Texas Southern | 21 | @ | Grambling | 58 | SWAC | |||
| 11/5/2005 | Grambling | 32 | @ | Alabama St | 27 | SWAC | |||
| 11/12/2005 | Concordia AL | 7 | @ | Grambling | 82 | ||||
| 11/26/2005 | Grambling | 50 | vs | Southern Univ | 35 | SWAC | |||
| 12/3/2005 | Grambling | 46 | @ | Alcorn St | 19 | SWAC |