| 9/10/2005 | Paul Quinn | 13 | @ | Prairie View | 39 | ||||
| 9/17/2005 | Prairie View | 0 | @ | Southern Univ | 38 | SWAC | |||
| 10/1/2005 | Grambling | 50 | vs | Prairie View | 7 | SWAC | Dallas TX | ||
| 10/8/2005 | Prairie View | 10 | @ | Alcorn St | 22 | SWAC | |||
| 10/15/2005 | Prairie View | 13 | @ | Alabama St | 34 | SWAC | |||
| 10/22/2005 | Prairie View | 40 | @ | Lincoln MO | 8 | ||||
| 10/29/2005 | MS Valley St | 58 | @ | Prairie View | 13 | SWAC | |||
| 11/5/2005 | Prairie View | 34 | @ | Ark Pine Bluff | 7 | SWAC | |||
| 11/12/2005 | Jackson St | 9 | @ | Prairie View | 27 | SWAC | |||
| 11/19/2005 | Alabama A&M | 31 | @ | Prairie View | 16 | SWAC |