| 9/10/2005 | Alabama St | 27 | @ | Texas Southern | 15 | SWAC | |||
| 9/17/2005 | Texas Southern | 21 | @ | Jackson St | 24 | SWAC | |||
| 10/1/2005 | Texas Southern | 17 | @ | Alabama A&M | 7 | SWAC | |||
| 10/8/2005 | Texas Southern | 28 | @ | McNeese St | 46 | ||||
| 10/15/2005 | Alcorn St | 29 | @ | Texas Southern | 22 | SWAC | |||
| 10/22/2005 | Texas Southern | 28 | @ | MS Valley St | 35 | SWAC | |||
| 10/29/2005 | Texas Southern | 21 | @ | Grambling | 58 | SWAC | |||
| 11/5/2005 | Southern Univ | 44 | @ | Texas Southern | 20 | SWAC | |||
| 11/12/2005 | Texas Southern | 0 | @ | UTEP | 45 | ||||
| 11/19/2005 | Ark Pine Bluff | 40 | @ | Texas Southern | 23 | SWAC |