| 9/3/2005 | MS Valley St | 30 | vs | Ark Pine Bluff | 17 | SWAC | Chicago IL | ||
| 9/10/2005 | Southern Univ | 28 | @ | MS Valley St | 31 | SWAC | |||
| 9/17/2005 | MS Valley St | 13 | @ | Alabama A&M | 27 | SWAC | |||
| 9/24/2005 | Jackson St | 33 | @ | MS Valley St | 14 | SWAC | |||
| 10/8/2005 | MS Valley St | 22 | @ | Grambling | 37 | SWAC | |||
| 10/15/2005 | MS Valley St | 62 | @ | Paul Quinn | 0 | ||||
| 10/22/2005 | Texas Southern | 28 | @ | MS Valley St | 35 | SWAC | |||
| 10/29/2005 | MS Valley St | 58 | @ | Prairie View | 13 | SWAC | |||
| 11/5/2005 | MS Valley St | 36 | @ | Alcorn St | 38 | SWAC | |||
| 11/12/2005 | Alabama St | 33 | @ | MS Valley St | 38 | SWAC | |||
| 11/19/2005 | SE Louisiana | 38 | @ | MS Valley St | 21 |