| 9/3/2005 | S Carolina St | 27 | vs | Alabama St | 14 | Birmingham AL | |||
| 9/10/2005 | Alabama St | 27 | @ | Texas Southern | 15 | SWAC | |||
| 9/17/2005 | Alabama St | 41 | @ | Ark Pine Bluff | 10 | SWAC | |||
| 9/24/2005 | Alcorn St | 3 | @ | Alabama St | 38 | SWAC | |||
| 10/1/2005 | Southern Univ | 35 | vs | Alabama St | 45 | SWAC | Mobile AL | ||
| 10/8/2005 | Alabama St | 44 | @ | Jackson St | 23 | SWAC | |||
| 10/15/2005 | Prairie View | 13 | @ | Alabama St | 34 | SWAC | |||
| 10/29/2005 | Alabama St | 28 | vs | Alabama A&M | 31 | SWAC | Birmingham AL | ||
| 11/5/2005 | Grambling | 32 | @ | Alabama St | 27 | SWAC | |||
| 11/12/2005 | Alabama St | 33 | @ | MS Valley St | 38 | SWAC | |||
| 11/24/2005 | Tuskegee | 28 | @ | Alabama St | 27 | OT |