| 9/10/2005 | Southern Univ | 28 | @ | MS Valley St | 31 | SWAC | |||
| 9/17/2005 | Prairie View | 0 | @ | Southern Univ | 38 | SWAC | |||
| 10/1/2005 | Southern Univ | 35 | vs | Alabama St | 45 | SWAC | Mobile AL | ||
| 10/8/2005 | Alabama A&M | 20 | @ | Southern Univ | 7 | SWAC | |||
| 10/15/2005 | Jackson St | 14 | @ | Southern Univ | 20 | SWAC | |||
| 10/22/2005 | Alcorn St | 38 | @ | Southern Univ | 16 | SWAC | |||
| 11/5/2005 | Southern Univ | 44 | @ | Texas Southern | 20 | SWAC | |||
| 11/12/2005 | Southern Univ | 27 | @ | Ark Pine Bluff | 21 | SWAC | |||
| 11/26/2005 | Grambling | 50 | vs | Southern Univ | 35 | SWAC |