| 9/1/2005 | West Virginia Tech | 3 | @ | Western Kentucky | 63 | ||||
| 9/10/2005 | Eastern Kentucky | 21 | @ | Western Kentucky | 23 | ||||
| 9/24/2005 | Western Kentucky | 14 | @ | #7 Auburn | 37 | ||||
| 10/1/2005 | Western Kentucky | 38 | @ | Indiana St | 28 | GW | |||
| 10/8/2005 | Western Kentucky | 37 | @ | Illinois St | 34 | GW | |||
| 10/15/2005 | Missouri State | 28 | @ | Western Kentucky | 37 | GW | |||
| 10/22/2005 | Western Kentucky | 42 | @ | Western Illinois | 7 | GW | |||
| 10/27/2005 | Southern Illinois | 31 | @ | Western Kentucky | 20 | GW | |||
| 11/5/2005 | Northern Iowa | 17 | @ | Western Kentucky | 20 | 2 OT | GW | ||
| 11/12/2005 | Western Kentucky | 10 | @ | Youngstown St | 42 | GW | |||
| 11/19/2005 | Western Kentucky | 35 | @ | Florida Intl | 38 |