| 9/3/2005 | S Carolina St | 27 | vs | Alabama St | 14 | Birmingham AL | |||
| 9/10/2005 | Winston-Salem St | 12 | @ | S Carolina St | 52 | ||||
| 9/17/2005 | S Carolina St | 27 | vs | Bethune-Cookman | 24 | MEAC | Jacksonville FL | ||
| 10/1/2005 | Coastal Car | 24 | @ | S Carolina St | 23 | ||||
| 10/6/2005 | S Carolina St | 35 | @ | Norfolk St | 21 | MEAC | |||
| 10/15/2005 | Florida A&M | 3 | @ | S Carolina St | 49 | MEAC | |||
| 10/22/2005 | S Carolina St | 10 | @ | Hampton | 14 | MEAC | |||
| 10/29/2005 | Delaware St | 3 | @ | S Carolina St | 24 | MEAC | |||
| 11/5/2005 | S Carolina St | 23 | @ | Howard | 9 | MEAC | |||
| 11/10/2005 | Morgan St | 15 | @ | S Carolina St | 65 | MEAC | |||
| 11/19/2005 | S Carolina St | 43 | vs | NC A&T | 27 | MEAC | Charlotte NC |