| 9/3/2022 | Johns Hopkins (10-1) | 54 | at | Case Western Reserve | 14 | Cen | ||
| 9/10/2022 | Case Western Reserve | 45 | at | Waynesburg (4-6,3-6) | 31 | |||
| 9/17/2022 | Washington & Jefferson (9-2,7-2) | 10 | at | Case Western Reserve | 14 | |||
| 9/24/2022 | Case Western Reserve | 34 | at | Geneva (3-7,3-6) | 7 | |||
| 10/1/2022 | Case Western Reserve | 13 | at | Grove City (8-3,6-3) | 14 | |||
| 10/8/2022 | St Vincent (5-5,5-4) | 21 | at | Case Western Reserve | 45 | |||
| 10/22/2022 | Bethany WV (1-9,0-9) | 7 | at | Case Western Reserve | 45 | |||
| 10/29/2022 | Case Western Reserve | 54 | at | Allegheny (3-7,3-6) | 7 | |||
| 11/5/2022 | Case Western Reserve | 13 | at | Westminster PA (7-3,7-2) | 14 | |||
| 11/12/2022 | Carnegie Mellon (11-1,8-0) | 20 | at | Case Western Reserve | 7 |
| vs Case Western Reserve | vs Other Opponents | Case Western Reserve compared to OOs | |
| Record: | 4-6 | 57-38 | |
| Points Scored: | 18.50 | 29.79 | 11.29 |
| Points Allowed: | 28.40 | 22.42 | 5.98 |
| Margin: | -9.90 | 7.37 | 17.27 |
| Total Points: | 46.90 | 52.21 | -5.31 |