| 9/3/2022 | John Carroll | 26 | at | Washington & Jefferson (9-2) | 35 | at TPAC | ||
| 9/17/2022 | Baldwin-Wallace (7-3,7-2) | 7 | at | John Carroll | 21 | |||
| 9/24/2022 | Heidelberg (7-3,6-3) | 7 | at | John Carroll | 24 | |||
| 10/1/2022 | John Carroll | 59 | at | Wilmington (3-7,2-7) | 0 | |||
| 10/8/2022 | Marietta (6-4,5-4) | 10 | at | John Carroll | 45 | |||
| 10/15/2022 | John Carroll | 24 | at | Ohio Northern (3-7,3-6) | 7 | |||
| 10/22/2022 | Capital (0-10,0-9) | 10 | at | John Carroll | 42 | |||
| 10/29/2022 | John Carroll | 49 | at | Muskingum (5-5,4-5) | 14 | |||
| 11/5/2022 | John Carroll | 28 | at | Mount Union (14-1,9-0) | 34 | |||
| 11/12/2022 | Otterbein (2-8,1-8) | 7 | at | John Carroll | 62 |
| vs John Carroll | vs Other Opponents | John Carroll compared to OOs | |
| Record: | 2-8 | 54-42 | |
| Points Scored: | 13.10 | 28.01 | 14.91 |
| Points Allowed: | 38.00 | 22.79 | 15.21 |
| Margin: | -24.90 | 5.22 | 30.12 |
| Total Points: | 51.10 | 50.80 | 0.30 |