| 9/3/2022 | Manchester | 23 | at | North Park (1-9) | 14 | at CCIW | ||
| 9/10/2022 | Manchester | 7 | at | Alma (11-1) | 49 | at MIAA | ||
| 9/17/2022 | Manchester | 22 | at | Greenville (7-3) | 49 | at UMWAC | ||
| 10/1/2022 | Mt St Joseph (10-1,7-0) | 55 | at | Manchester | 20 | |||
| 10/8/2022 | Manchester | 14 | at | Rose-Hulman (6-4,6-1) | 48 | |||
| 10/15/2022 | Hanover (5-5,5-2) | 51 | at | Manchester | 20 | |||
| 10/22/2022 | Bluffton (2-8,2-5) | 46 | at | Manchester | 44 | 5OT | ||
| 10/29/2022 | Franklin (4-6,4-3) | 24 | at | Manchester | 6 | |||
| 11/5/2022 | Manchester | 21 | at | Defiance (3-7,3-4) | 24 | |||
| 11/12/2022 | Manchester | 12 | at | Anderson (1-9,1-6) | 19 |
| vs Manchester | vs Other Opponents | Manchester compared to OOs | |
| Record: | 9-1 | 41-52 | |
| Points Scored: | 37.90 | 28.49 | -9.41 |
| Points Allowed: | 18.90 | 32.95 | -14.05 |
| Margin: | 19.00 | -4.46 | -23.46 |
| Total Points: | 56.80 | 61.44 | -4.64 |