| 9/1/2022 | Barton (4-7) | 17 | at | Chowan | 3 | SAC | ||
| 9/10/2022 | Tusculum (8-3) | 23 | at | Chowan | 21 | SAC | ||
| 9/17/2022 | Johnson C Smith (2-7,2-6) | 29 | at | Chowan | 32 | |||
| 9/24/2022 | Winston-Salem State (3-6,3-4) | 7 | at | Chowan | 21 | |||
| 9/29/2022 | Chowan | 10 | at | Fayetteville State (9-3,8-1) | 13 | |||
| 10/8/2022 | Chowan | 16 | at | Lincoln PA (2-7,1-6) | 14 | |||
| 10/15/2022 | Virginia State (6-4,5-3) | 40 | at | Chowan | 43 | |||
| 10/22/2022 | Chowan | 21 | at | Bowie State (6-4,5-3) | 15 | |||
| 10/29/2022 | Chowan | 26 | at | Virginia Union (9-2,7-1) | 21 | |||
| 11/5/2022 | Elizabeth City State (2-8,2-7) | 8 | at | Chowan | 54 | |||
| 11/12/2022 | Fayetteville State (9-3,8-1) | 31 | at | Chowan | 28 |
| vs Chowan | vs Other Opponents | Chowan compared to OOs | |
| Record: | 4-7 | 54-47 | |
| Points Scored: | 19.82 | 26.03 | 6.21 |
| Points Allowed: | 25.00 | 22.97 | 2.03 |
| Margin: | -5.18 | 3.06 | 8.24 |
| Total Points: | 44.82 | 49.00 | -4.18 |