| 9/1/2022 | Arkansas Tech (5-6,5-6) | 34 | at | Southeastern Oklahoma State | 41 | OT | | |
| 9/10/2022 | Southeastern Oklahoma State | 13 | at | Harding (9-2,9-2) | 38 | | | |
| 9/17/2022 | Southeastern Oklahoma State | 58 | at | Southwestern Oklahoma State (4-7,4-7) | 48 | | | |
| 9/24/2022 | Southern Nazarene (5-6,5-6) | 45 | at | Southeastern Oklahoma State | 34 | | | |
| 10/1/2022 | Southeastern Oklahoma State | 23 | at | Henderson State (8-3,8-3) | 31 | | | |
| 10/8/2022 | Southern Arkansas (5-6,5-6) | 32 | at | Southeastern Oklahoma State | 35 | | | |
| 10/15/2022 | Southeastern Oklahoma State | 44 | at | Northwestern Oklahoma State (1-10,1-10) | 7 | | | |
| 10/22/2022 | Oklahoma Baptist (1-10,1-10) | 14 | at | Southeastern Oklahoma State | 62 | | | |
| 10/29/2022 | Southeastern Oklahoma State | 48 | at | Arkansas-Monticello (3-8,3-8) | 20 | | | |
| 11/5/2022 | Ouachita (11-1,11-0) | 40 | at | Southeastern Oklahoma State | 18 | | | |
| 11/12/2022 | Southeastern Oklahoma State | 10 | at | East Central (9-3,8-3) | 31 | | | |
| 12/3/2022 | Southeastern Oklahoma State | 27 | vs | Emporia State (9-3) | 48 | | Texarkana AR | vs MAIAA |