| 9/1/2022 | Ouachita (11-1,11-0) | 42 | at | Oklahoma Baptist | 32 | | | |
| 9/10/2022 | Oklahoma Baptist | 17 | at | Arkansas-Monticello (3-8,3-8) | 40 | | | |
| 9/17/2022 | Oklahoma Baptist | 31 | at | Northwestern Oklahoma State (1-10,1-10) | 23 | | | |
| 9/24/2022 | Southwestern Oklahoma State (4-7,4-7) | 38 | at | Oklahoma Baptist | 31 | OT | | |
| 10/1/2022 | Oklahoma Baptist | 23 | at | Harding (9-2,9-2) | 38 | | | |
| 10/8/2022 | Arkansas Tech (5-6,5-6) | 34 | at | Oklahoma Baptist | 13 | | | |
| 10/15/2022 | East Central (9-3,8-3) | 34 | at | Oklahoma Baptist | 20 | | | |
| 10/22/2022 | Oklahoma Baptist | 14 | at | Southeastern Oklahoma State (6-6,6-5) | 62 | | | |
| 10/29/2022 | Southern Arkansas (5-6,5-6) | 52 | at | Oklahoma Baptist | 20 | | | |
| 11/5/2022 | Oklahoma Baptist | 24 | at | Henderson State (8-3,8-3) | 51 | | | |
| 11/12/2022 | Southern Nazarene (5-6,5-6) | 56 | at | Oklahoma Baptist | 21 | | | |