| 9/1/2022 | Northeastern State (1-10,1-10) | 17 | at | Emporia State | 42 | | | |
| 9/8/2022 | Emporia State | 13 | at | Central Oklahoma (6-5,6-5) | 21 | | | |
| 9/17/2022 | Missouri Western (5-6,5-6) | 12 | at | Emporia State | 36 | | | |
| 9/24/2022 | Pittsburg State (12-1,11-0) | 14 | at | Emporia State | 13 | | | |
| 10/1/2022 | Emporia State | 42 | at | Washburn (7-4,7-4) | 35 | | | |
| 10/8/2022 | Central Missouri (4-7,4-7) | 27 | at | Emporia State | 44 | | | |
| 10/15/2022 | Emporia State | 44 | at | Nebraska-Kearney (8-3,8-3) | 21 | | | |
| 10/22/2022 | Emporia State | 24 | at | Missouri Southern (4-7,4-7) | 21 | | | |
| 10/29/2022 | Fort Hays State (3-8,3-8) | 14 | at | Emporia State | 42 | | | |
| 11/5/2022 | Emporia State | 35 | at | Lincoln MO (0-11,0-11) | 24 | | | |
| 11/12/2022 | Northwest Missouri State (10-3,9-2) | 27 | at | Emporia State | 21 | | | |
| 12/3/2022 | Southeastern Oklahoma State (6-6) | 27 | vs | Emporia State | 48 | | Texarkana AR | GAC |