| 9/1/2022 | Harding (9-2,9-2) | 29 | at | East Central | 12 | | | |
| 9/10/2022 | East Central | 13 | at | Arkansas Tech (5-6,5-6) | 35 | | | |
| 9/17/2022 | East Central | 44 | at | Southern Nazarene (5-6,5-6) | 21 | | | |
| 9/24/2022 | Northwestern Oklahoma State (1-10,1-10) | 3 | at | East Central | 31 | | | |
| 10/1/2022 | East Central | 34 | at | Southern Arkansas (5-6,5-6) | 22 | | | |
| 10/8/2022 | Henderson State (8-3,8-3) | 10 | at | East Central | 31 | | | |
| 10/15/2022 | East Central | 34 | at | Oklahoma Baptist (1-10,1-10) | 20 | | | |
| 10/22/2022 | Southwestern Oklahoma State (4-7,4-7) | 28 | at | East Central | 42 | | | |
| 10/27/2022 | East Central | 18 | at | Ouachita (11-1,11-0) | 28 | | | |
| 11/5/2022 | Arkansas-Monticello (3-8,3-8) | 0 | at | East Central | 16 | | | |
| 11/12/2022 | Southeastern Oklahoma State (6-6,6-5) | 10 | at | East Central | 31 | | | |
| 12/3/2022 | East Central | 38 | vs | Texas A&M-Kingsville (7-5) | 21 | | Corsicana TX | vs LSC |