| 9/1/2022 | Northwestern Oklahoma State | 31 | at | Southern Arkansas (5-6,5-6) | 62 | | | |
| 9/10/2022 | Henderson State (8-3,8-3) | 51 | at | Northwestern Oklahoma State | 27 | | | |
| 9/17/2022 | Oklahoma Baptist (1-10,1-10) | 31 | at | Northwestern Oklahoma State | 23 | | | |
| 9/24/2022 | Northwestern Oklahoma State | 3 | at | East Central (9-3,8-3) | 31 | | | |
| 10/1/2022 | Ouachita (11-1,11-0) | 48 | at | Northwestern Oklahoma State | 7 | | | |
| 10/8/2022 | Northwestern Oklahoma State | 26 | at | Arkansas-Monticello (3-8,3-8) | 23 | | | |
| 10/15/2022 | Southeastern Oklahoma State (6-6,6-5) | 44 | at | Northwestern Oklahoma State | 7 | | | |
| 10/22/2022 | Northwestern Oklahoma State | 21 | at | Southern Nazarene (5-6,5-6) | 27 | | | |
| 10/29/2022 | Northwestern Oklahoma State | 7 | at | Harding (9-2,9-2) | 28 | | | |
| 11/5/2022 | Arkansas Tech (5-6,5-6) | 45 | at | Northwestern Oklahoma State | 20 | | | |
| 11/12/2022 | Northwestern Oklahoma State | 28 | at | Southwestern Oklahoma State (4-7,4-7) | 41 | | | |