| 9/1/2022 | Southwestern Oklahoma State (4-7,4-7) | 13 | at | Henderson State | 30 | | | |
| 9/10/2022 | Henderson State | 51 | at | Northwestern Oklahoma State (1-10,1-10) | 27 | | | |
| 9/17/2022 | Arkansas-Monticello (3-8,3-8) | 27 | at | Henderson State | 37 | | | |
| 9/24/2022 | Henderson State | 24 | at | Southern Arkansas (5-6,5-6) | 28 | | | |
| 10/1/2022 | Southeastern Oklahoma State (6-6,6-5) | 23 | at | Henderson State | 31 | | | |
| 10/8/2022 | Henderson State | 10 | at | East Central (9-3,8-3) | 31 | | | |
| 10/15/2022 | Henderson State | 15 | at | Harding (9-2,9-2) | 14 | | | |
| 10/22/2022 | Arkansas Tech (5-6,5-6) | 19 | at | Henderson State | 35 | | | |
| 10/29/2022 | Henderson State | 42 | at | Southern Nazarene (5-6,5-6) | 41 | OT | | |
| 11/5/2022 | Oklahoma Baptist (1-10,1-10) | 24 | at | Henderson State | 51 | | | |
| 11/12/2022 | Ouachita (11-1,11-0) | 40 | at | Henderson State | 37 | OT | | |