| 9/1/2022 | Ouachita | 42 | at | Oklahoma Baptist (1-10,1-10) | 32 | | | |
| 9/10/2022 | Southern Nazarene (5-6,5-6) | 0 | at | Ouachita | 45 | | | |
| 9/17/2022 | Ouachita | 63 | at | Arkansas Tech (5-6,5-6) | 14 | | | |
| 9/24/2022 | Harding (9-2,9-2) | 13 | at | Ouachita | 21 | | | |
| 10/1/2022 | Ouachita | 48 | at | Northwestern Oklahoma State (1-10,1-10) | 7 | | | |
| 10/8/2022 | Southwestern Oklahoma State (4-7,4-7) | 24 | at | Ouachita | 63 | | | |
| 10/15/2022 | Arkansas-Monticello (3-8,3-8) | 7 | at | Ouachita | 41 | | | |
| 10/22/2022 | Southern Arkansas (5-6,5-6) | 31 | vs | Ouachita | 63 | | El Dorado AR | |
| 10/27/2022 | East Central (9-3,8-3) | 18 | at | Ouachita | 28 | | | |
| 11/5/2022 | Ouachita | 40 | at | Southeastern Oklahoma State (6-6,6-5) | 18 | | | |
| 11/12/2022 | Ouachita | 40 | at | Henderson State (8-3,8-3) | 37 | OT | | |
| 11/19/2022 | Northwest Missouri State (10-3) | 47 | at | Ouachita | 17 | | D2 Championship Round 1 | MAIAA |