| 9/1/2022 | Southwestern Oklahoma State | 13 | at | Henderson State (8-3,8-3) | 30 | | | |
| 9/10/2022 | Southern Arkansas (5-6,5-6) | 20 | at | Southwestern Oklahoma State | 24 | | | |
| 9/17/2022 | Southeastern Oklahoma State (6-6,6-5) | 58 | at | Southwestern Oklahoma State | 48 | | | |
| 9/24/2022 | Southwestern Oklahoma State | 38 | at | Oklahoma Baptist (1-10,1-10) | 31 | OT | | |
| 10/1/2022 | Arkansas-Monticello (3-8,3-8) | 27 | at | Southwestern Oklahoma State | 37 | | | |
| 10/8/2022 | Southwestern Oklahoma State | 24 | at | Ouachita (11-1,11-0) | 63 | | | |
| 10/15/2022 | Southern Nazarene (5-6,5-6) | 45 | at | Southwestern Oklahoma State | 38 | | | |
| 10/22/2022 | Southwestern Oklahoma State | 28 | at | East Central (9-3,8-3) | 42 | | | |
| 10/29/2022 | Southwestern Oklahoma State | 21 | at | Arkansas Tech (5-6,5-6) | 22 | | | |
| 11/5/2022 | Harding (9-2,9-2) | 37 | at | Southwestern Oklahoma State | 29 | | | |
| 11/12/2022 | Northwestern Oklahoma State (1-10,1-10) | 28 | at | Southwestern Oklahoma State | 41 | | | |