| 9/3/2022 | Hamline | 39 | at | Crown | 14 | MIA | ||
| Ill. Benedictine | 52 | at | Finlandia | 7 | NAC | |||
| Westminster MO | 0 | at | Knox | 26 | @ MidW | |||
| Concordia WI | 35 | at | Martin Luther | 14 | NAC | |||
| Greenville | 14 | at | Millikin | 28 | @ CCIW | |||
| Macalester | 45 | at | Minnesota-Morris | 24 | MIA | |||
| Augsburg | 23 | at | Northwestern MN | 15 | MIA | |||
| 9/10/2022 | Crown | 20 | at | Carleton | 84 | @ MIA | ||
| Finlandia | 7 | at | Concordia IL | 45 | @ NAC | |||
| Northwestern MN | 14 | at | Concordia WI | 28 | @ NAC | |||
| Rockford | 30 | at | Greenville | 40 | NAC | |||
| Minnesota-Morris | 21 | at | Hamline | 34 | @ MIA | |||
| Martin Luther | 7 | at | Macalester | 43 | @ MIA | |||
| Iowa Wesleyan | 41 | at | Westminster MO | 6 | NSAA (NAIA) | |||
| 9/17/2022 | Minnesota-Morris | 7 | at | Carleton | 41 | @ MIA | ||
| St Scholastica | 63 | at | Crown | 14 | MIA | |||
| Manchester | 22 | at | Greenville | 49 | HCA | |||
| Finlandia | 0 | at | Iowa Wesleyan | 55 | @ NSAA (NAIA) | |||
| Augsburg | 45 | at | Martin Luther | 7 | MIA | |||
| Westminster MO | 6 | at | Sewanee | 41 | @ SAA | |||
| Northwestern MN | 27 | at | Wisconsin-River Falls | 63 | @ WIAC | |||
| 9/24/2022 | Finlandia | 13 | at | Adrian | 73 | @ MIAA | ||
| Martin Luther | 0 | at | Alma | 69 | @ MIAA | |||
| Olivet | 63 | at | Greenville | 7 | MIAA | |||
| Lawrence | 19 | at | Minnesota-Morris | 49 | MidW | |||
| Hope | 56 | at | Northwestern MN | 7 | MIAA | |||
| Westminster MO | 6 | at | Rhodes | 56 | @ SAA | |||
| Crown | 6 | at | Wisconsin-Stout | 66 | @ WIAC | |||
| 10/1/2022 | Northwestern MN | 30 | at | Finlandia | 0 | |||
| Martin Luther | 27 | at | Greenville | 30 | ||||
| Minnesota-Morris | 28 | at | Westminster MO | 8 | ||||
| 10/8/2022 | Crown | 26 | at | Martin Luther | 20 | |||
| Finlandia | 12 | at | Minnesota-Morris | 28 | ||||
| Greenville | 35 | at | Northwestern MN | 41 | ||||
| 10/15/2022 | Minnesota-Morris | 27 | at | Crown | 0 | |||
| Westminster MO | 0 | at | Greenville | 52 | ||||
| Finlandia | 0 | at | Martin Luther | 34 | ||||
| 10/22/2022 | Crown | 40 | at | Finlandia | 14 | |||
| Martin Luther | 0 | at | Minnesota-Morris | 47 | ||||
| Northwestern MN | 36 | at | Westminster MO | 0 | ||||
| 10/29/2022 | Greenville | 48 | at | Crown | 6 | |||
| Westminster MO | 16 | at | Finlandia | 12 | ||||
| Minnesota-Morris | 24 | at | Northwestern MN | 31 | ||||
| 11/5/2022 | Northwestern MN | 39 | at | Crown | 14 | |||
| Finlandia | 7 | at | Greenville | 45 | ||||
| Westminster MO | 7 | at | Martin Luther | 10 | ||||
| 11/12/2022 | Greenville | 43 | at | Minnesota-Morris | 25 | |||
| Martin Luther | 9 | at | Northwestern MN | 31 | ||||
| Crown | 26 | at | Westminster MO | 22 | ||||
| 11/19/2022 | Northwestern MN | 0 | at | St John's MN | 49 | D3 Championship Round 1 | @ MIA |