| 9/3/2022 | Greenville (7-3) | 14 | at | Millikin | 28 | UMWAC | ||
| 9/17/2022 | Millikin | 7 | at | Washington U (8-3,7-2) | 54 | |||
| 9/24/2022 | North Park (1-9,1-8) | 21 | at | Millikin | 23 | |||
| 10/1/2022 | Millikin | 24 | at | Illinois Wesleyan (6-4,5-4) | 38 | |||
| 10/8/2022 | Augustana IL (5-5,4-5) | 70 | at | Millikin | 0 | |||
| 10/15/2022 | Millikin | 0 | at | North Central (15-0,9-0) | 65 | |||
| 10/22/2022 | Elmhurst (0-10,0-9) | 0 | at | Millikin | 13 | |||
| 10/29/2022 | Millikin | 3 | at | Wheaton (8-3,8-1) | 69 | |||
| 11/5/2022 | Carroll WI (6-4,5-4) | 26 | at | Millikin | 18 | |||
| 11/12/2022 | Millikin | 17 | at | Carthage (3-7,3-6) | 6 |
| vs Millikin | vs Other Opponents | Millikin compared to OOs | |
| Record: | 6-4 | 53-44 | |
| Points Scored: | 36.30 | 32.29 | -4.01 |
| Points Allowed: | 13.30 | 29.05 | -15.75 |
| Margin: | 23.00 | 3.24 | -19.76 |
| Total Points: | 49.60 | 61.34 | -11.74 |