| 9/3/2022 | Westminster MO (1-9) | 0 | at | Knox | 26 | UMWAC | ||
| 9/10/2022 | Knox | 6 | at | Ripon (9-1,8-1) | 33 | |||
| 9/17/2022 | Knox | 14 | at | Lake Forest (9-2,8-1) | 48 | |||
| 10/1/2022 | Chicago (7-3,6-3) | 50 | at | Knox | 14 | |||
| 10/8/2022 | Knox | 34 | at | Beloit (1-9,1-8) | 25 | |||
| 10/15/2022 | Grinnell (2-6,2-6) | 7 | at | Knox | 28 | |||
| 10/22/2022 | Illinois College (5-4,4-4) | 20 | at | Knox | 10 | |||
| 10/29/2022 | Knox | 35 | at | Lawrence (0-10,0-9) | 0 | |||
| 11/5/2022 | Knox | 31 | at | Cornell IA (3-7,3-6) | 27 | |||
| 11/12/2022 | Monmouth IL (9-2,8-1) | 56 | at | Knox | 0 |
| vs Knox | vs Other Opponents | Knox compared to OOs | |
| Record: | 5-5 | 41-48 | |
| Points Scored: | 26.60 | 24.04 | -2.56 |
| Points Allowed: | 19.80 | 27.56 | -7.76 |
| Margin: | 6.80 | -3.52 | -10.32 |
| Total Points: | 46.40 | 51.60 | -5.20 |