| 8/27/2022 | Tabor (6-5) | 17 | at | Iowa Wesleyan | 13 | KCAC | ||
| 9/3/2022 | Iowa Wesleyan | 23 | at | Missouri Baptist (4-7) | 25 | 3OT | at MSFA | |
| 9/10/2022 | Iowa Wesleyan | 41 | at | Westminster MO (1-9) | 6 | at UMWAC | ||
| 9/17/2022 | Finlandia (0-10) | 0 | at | Iowa Wesleyan | 55 | UMWAC (D3) | ||
| 9/24/2022 | Iowa Wesleyan | 7 | at | Dakota State (6-4,5-3) | 24 | |||
| 10/1/2022 | Mayville State (3-8,1-7) | 38 | at | Iowa Wesleyan | 42 | |||
| 10/8/2022 | Dickinson State (8-3,8-0) | 23 | at | Iowa Wesleyan | 0 | |||
| 10/15/2022 | Iowa Wesleyan | 0 | at | Valley City State (5-5,5-3) | 32 | |||
| 10/22/2022 | Iowa Wesleyan | 49 | at | Presentation (3-8,2-6) | 22 | |||
| 10/29/2022 | Dakota State (6-4,5-3) | 12 | at | Iowa Wesleyan | 6 | |||
| 11/5/2022 | Iowa Wesleyan | 3 | at | Waldorf (7-4,4-3) | 7 |
| vs Iowa Wesleyan | vs Other Opponents | Iowa Wesleyan compared to OOs | |
| Record: | 7-4 | 40-63 | |
| Points Scored: | 18.73 | 20.19 | 1.46 |
| Points Allowed: | 21.73 | 28.88 | -7.15 |
| Margin: | -3.00 | -8.69 | -5.69 |
| Total Points: | 40.46 | 49.07 | -8.61 |