| 9/3/2022 | Notre Dame | 10 | at | Ohio State | 21 | @ B10 | ||
| 9/10/2022 | Marshall | 26 | at | Notre Dame | 21 | SBC | ||
| 9/17/2022 | California | 17 | at | Notre Dame | 24 | P12 | ||
| 9/24/2022 | Notre Dame | 45 | at | North Carolina | 32 | @ ACC | ||
| 10/8/2022 | BYU | 20 | at | Notre Dame | 28 | Las Vegas NV | Ind | |
| 10/15/2022 | Stanford | 16 | at | Notre Dame | 14 | P12 | ||
| 10/22/2022 | UNLV | 21 | at | Notre Dame | 44 | MW | ||
| 10/29/2022 | Notre Dame | 41 | at | Syracuse | 24 | @ ACC | ||
| 11/5/2022 | Clemson | 14 | at | Notre Dame | 35 | ACC | ||
| 11/12/2022 | Notre Dame | 35 | vs | Navy | 32 | Baltimore MD | vs AAC | |
| 11/19/2022 | Boston College | 0 | at | Notre Dame | 44 | ACC | ||
| 11/26/2022 | Notre Dame | 27 | at | Southern California | 38 | @ P12 | ||
| 12/30/2022 | Notre Dame | 45 | vs | South Carolina | 38 | Jacksonville FL | vs SEC |